Inventum Biologicum: An International Journal of Biological Research

Myosatellite Cells: The Architects of Muscle Regeneration and Repair

Dr. Mayalata Dimpal — Thu, 13 Mar 2025 00:00:00 +0000

Myosatellite cells, also referred to as satellite cells, are muscle-specific stem cells that play a crucial role in skeletal muscle regeneration, growth, and repair. These cells sit nestled between the basal lamina and sarcolemma of muscle fibers, and upon activation, they proliferate and differentiate into new myofibers. This monograph gives an overview of the biology, function, and therapeutic potential of myosatellite cells, with integration of recent scientific advances. Their effects in muscle homeostasis, the molecular mechanisms regulating their activation, and the regenerative medicine potential are discussed. Future directions for research and clinical applications conclude the review.

A Comprehensive Review on Secondary Metabolite of Lichens

Sun, 09 Mar 2025 00:00:00 +0000

Unique organisms and lichen-forming fungi produce physiologically active compounds with a wide range of actions, including cytotoxic, antimycobacterial, antiviral, anti-inflammatory, analgesic, antipyretic, and antiproliferative properties. Nevertheless, very few lichen compounds have been examined for their biological and medicinal properties in medicine. This is undoubtedly a result of the challenges involved in species identification, bulk quantity collection, and isolation of pure chemicals for testing and structural determination. This involves synthesizing natural products or their derivatives for testing, extracting targeted chemicals, or using axenic cultures to produce new or authentic substances. Synthetic antioxidants that are often utilized are thought to have harmful and cancer-causing properties. As a result, there is an increasing interest in discovering novel natural resource antioxidants that are free of unwanted effects. Numerous in vitro investigations on plants, macromycetes, micro- and macroalgae, and lichens have provided compelling evidence that their antioxidant-capable elements can protect biological systems from oxidative stress. Because natural antioxidants have a preventive effect against oxidative stress and physiological dysfunction, their use is crucial. Lichens have piqued our interest in the search for novel natural antioxidant sources. Secondary metabolites, mainly phenols, which are well recognized for their antioxidant properties, are abundant in lichens.

Understanding and Addressing the Stigmatization of Schizophrenia

Janhavi Rai, Jitendra K. Rai — Fri, 31 Jan 2025 00:00:00 +0000

The stigmatization of schizophrenia represents a significant societal challenge that impacts the individuals living with the disorder. Stigma often arises from a lack of understanding, perpetuated by media portrayals and cultural narratives that associate schizophrenia with violence and unpredictability. Addressing stigma requires comprehensive public education, advocacy for policy changes, and the promotion of narratives that highlight the lived experiences of individuals with schizophrenia. Through these efforts, we can foster a more inclusive society that recognizes the complexities of mental health and encourages recovery and understanding. This article explores the multifaceted nature of stigma, including public misconceptions, discrimination, and the internalization of negative perceptions by those affected.

Furthermore, while many professionals aim to provide compassionate care, some may inadvertently reinforce stereotypes through biased language, diagnostic labels, or inadequate understanding of the disorder. This can lead to negative patient experiences, discouraging individuals from seeking help. As a result, individuals may face barriers in accessing treatment, employment, and social support, exacerbating their isolation and worsening mental health outcomes.

By identifying the sources and consequences of stigma, this article aims to contribute to the development of more inclusive, empathetic, and effective approaches to treating schizophrenia, ultimately improving the lives of individuals living with the disorder.

Impact of Wood Ash on Mulberry Plant Health and Cocoon Crop Productivity

Rubia Bukhari, Azad Gull, Nitish Singh Pangotra — Wed, 22 Jan 2025 00:00:00 +0000

Silkworms require a balanced and nutrient-dense diet to thrive and the quality of mulberry leaves plays a critical role in determining their health and feeding efficiency. Wood ash as an organic amendment in mulberry cultivation to enhance plant health and cocoon crop productivity within sericulture is one of the sustainable techniques to meet out the quality mulberry leaf. It is rich in essential nutrients such as potassium, calcium, phosphorus and trace minerals which serves as a multifaceted soil amendment that improves soil pH, nutrient density and plant structural integrity. These enhancements in mulberry plant vigour and disease resistance directly translate into improved leaf quality, which positively impacts silkworm health, cocoon yield and silk quality. Wood ash as a sustainable alternative to synthetic fertilizers, promoting nutrient recycling and reducing costs for farmers. However, precise application methods and optimal dosages require further research to maximize the advantages of wood ash while mitigating potential soil alkalinization. Ultimately, the use of wood ash aligns with sustainable agriculture goals, offering a cost-effective and eco-friendly approach that enhances mulberry productivity and supports the sericulture industry. This review article underscores the potential of wood ash to contribute to more resilient and sustainable sericulture practices.

Preparation of Organic Repellent for Pest Control in Solanaceae Crops

B. Mano, P. Tamizhmathy, S. Thamizhkani — Wed, 19 Feb 2025 00:00:00 +0000

An organic pest repellant is a natural solution for safeguarding plants from destructive pests. It employs substances derived from plants or essential oils to create a protective barrier that either repels or controls pests without causing harm to the environment or human health. This eco-friendly approach encourages a balanced eco system, promotes sustainable agriculture, and reduces the dependency on chemical pesticides. By adopting this method, we can preserve the health of our ecosystems and ensure a stable food supply.

Traditional Knowledge and Sustainable Use of Wild Edible and Medicinal Plants in Tirunelveli District, Tamil Nadu, India

Thu, 23 Jan 2025 00:00:00 +0000

This study investigates the traditional knowledge surrounding the use of wild edible and medicinal plants among traditional healers in Tirunelveli District, Tamil Nadu, India. These healers play a crucial role in safeguarding and transmitting indigenous wisdom about local flora with therapeutic and nutritional applications. By employing methods such as structured interviews, participant observation, and field visits, the research catalogs the diversity of plant species, their preparation techniques, and utilization patterns. The findings underscore the richness of traditional knowledge and the indispensable role wild plants play in local healthcare and nutrition systems. This study also emphasizes the urgent need to preserve this heritage in the face of modern challenges, offering valuable insights for future research and promoting the sustainable use of plant resources.

GCMS and ADME Profiling of Extract from Seeds of Passiflora edulis

Yashmitha S. Raj, Aishwarya Patil, Dhanya Bhat, Sharad S. Achar — Wed, 22 Jan 2025 00:00:00 +0000

Passiflora edulis is a tropical fruit from the family passifloraceae. It is used as a traditional medicine in the treatment of several ailments. However, preliminary studies and several literature have mentioned these seeds to possess huge medicinal properties. This study is based on Gas Chromatography-Mass Spectrometry (GCMS) and in-silico techniques (ADME) applied to identify the bioactive phytocompounds present in extracts of the seeds in the fruit. The parameters considered for analysis were molecular weight, lipophilicity, GI absorption, water solubility, drug-likeness, Lipinski rule of 5, blood-brain barrier permeability, synthetic accessibility, bioavailability, and lead likeness. Among the eleven phytocomponents subjected to ADME analysis, ten of them were found to possess medicinal properties and four were identified as novel to these extracts. The compounds found in the GCMS analysis were propanedioic acid, oxirane derivative, anthranilanilide, a cytotoxic agent, an anticancer agent, and an antiproliferative agent. The chemical compounds present in the seeds impart them with medicinal properties, which would allow one to understand the relationship between the different bioactive compounds in seeds and the human body. Further studies need to be performed to identify its potential in ameliorating the neurological properties.