GCMS and ADME Profiling of Extract from Seeds of Passiflora edulis
Keywords:
ADME, GCMS, Passiflora edulis, PhytocompoundAbstract
Passiflora edulis is a tropical fruit from the family passifloraceae. It is used as a traditional medicine in the treatment of several ailments. However, preliminary studies and several literature have mentioned these seeds to possess huge medicinal properties. This study is based on Gas Chromatography-Mass Spectrometry (GCMS) and in-silico techniques (ADME) applied to identify the bioactive phytocompounds present in extracts of the seeds in the fruit. The parameters considered for analysis were molecular weight, lipophilicity, GI absorption, water solubility, drug-likeness, Lipinski rule of 5, blood-brain barrier permeability, synthetic accessibility, bioavailability, and lead likeness. Among the eleven phytocomponents subjected to ADME analysis, ten of them were found to possess medicinal properties and four were identified as novel to these extracts. The compounds found in the GCMS analysis were propanedioic acid, oxirane derivative, anthranilanilide, a cytotoxic agent, an anticancer agent, and an antiproliferative agent. The chemical compounds present in the seeds impart them with medicinal properties, which would allow one to understand the relationship between the different bioactive compounds in seeds and the human body. Further studies need to be performed to identify its potential in ameliorating the neurological properties.
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Api, A. M. (2001). Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food and Chemical Toxicology, 39(2), 97–108. https://doi.org/10.1016/s0278-6915(00)00124-1
Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: a Free web Tool to Evaluate pharmacokinetics, drug-likeness and Medicinal Chemistry Friendliness of Small Molecules. Scientific Reports, 7(1), 1–13. https://doi.org/10.1038/srep42717
Diamante, C., Zondlo Fiume, M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2010). Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics. International Journal of Toxicology, 29(4_suppl), 137S150S. https://doi.org/10.1177/1091581810373150
Doogue, M. P., & Polasek, T. M. (2013). The ABCD of clinical pharmacokinetics. Therapeutic Advances in Drug Safety, 4(1), 5–7. https://doi.org/10.1177/2042098612469335
Jayalekshmi C, Rajiv Periakaruppan, Karungan Selvaraj Selvaraj, & Noura Al-Dayan. (2024). Spectroscopic Analysis of Bioactive Compounds from Latex of Calotropis gigantea L. and an Evaluation of Its Biological Activities. Analytica—a Journal of Analytical Chemistry and Chemical Analysis, 5(3), 384–401. https://doi.org/10.3390/analytica5030024
Łukasz Popiołek, Gawrońska-Grzywacz, M., Aleksandra Dziduch, Biernasiuk, A., Iwona Piątkowska-Chmiel, & Mariola Herbet. (2023). Design, Synthesis, and In Vitro and In Vivo Bioactivity Studies of Hydrazide–Hydrazones of 2,4-Dihydroxybenzoic Acid. International Journal of Molecular Sciences, 24(24), 17481–17481. https://doi.org/10.3390/ijms242417481
Stolfa, D. A., Stefanachi, A., Gajer, J. M., Nebbioso, A., Altucci, L., Cellamare, S., Jung, M., & Carotti, A. (2012). Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors. ChemMedChem, 7(7), 1256–1266. https://doi.org/10.1002/cmdc.201200193
Testa, B., & KrämerS. D. (2008). Principles, redox reactions, hydrolyses. Weinheim Wiley-Vch Zürich Verl. Helvetica Chimica Acta.
Vasudevan A, Kalarickal V., Dileep , Pradeep K. M, Ponnuraj K, Chittalakkottu S, Madathilkovilakathu H. (2012). Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment, Chem Biol Drug Des, 80, 434 – 439.
Zibadi Sherma, & Watson Ronald R. (2004). Passion Fruit (Passiflora edulis): Composition, Efficacy and Safety. Evidence-Based Integrative Medicine, 1(3), 183–187. https://www.researchgate.net/publication/233575438_Passion_Fruit_Passiflora_edulis_Composition_Efficacy_and_Safety
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