Myosatellite Cells: The Architects of Muscle Regeneration and Repair
Keywords:
Myosatellite cells, Skeletal muscle, Regeneration, Stem cells, Muscle repair, Regenerative medicineAbstract
Myosatellite cells, also referred to as satellite cells, are muscle-specific stem cells that play a crucial role in skeletal muscle regeneration, growth, and repair. These cells sit nestled between the basal lamina and sarcolemma of muscle fibers, and upon activation, they proliferate and differentiate into new myofibers. This monograph gives an overview of the biology, function, and therapeutic potential of myosatellite cells, with integration of recent scientific advances. Their effects in muscle homeostasis, the molecular mechanisms regulating their activation, and the regenerative medicine potential are discussed. Future directions for research and clinical applications conclude the review.
Downloads
References
Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2013). Building muscle: Molecular regulation of myogenesis. Cold Spring Harbor Perspectives in Biology, 5 (2), a 008342. https://doi.org/10.1101/cshperspect.a008342
Bjornson, C. R., Cheung, T. H., Liu, L., Tripathi, P. V., & Steeper, K. M. (2012). Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells, 30 (2), 232–242. https://doi.org/10.1002/stem.773
Blau, H. M., Cosgrove, B. D., & Ho, A. T. (2015). The central role of muscle stem cells in regenerative failure with aging. Nature Medicine, 21 (8), 854–862. https://doi.org/10.1038/nm.3918
Brack, A. S., Conboy, I. M., & Roy, S. (2008). Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science, 317 (5839), 807–810. https://doi.org/10.1126/science.1144090
Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008). Niche regulation of muscle satellite cell self-renewal and differentiation. Cell Stem Cell, 2 (1), 22–31. https://doi.org/10.1016/j.stem.2007.12.012
Mauro, A. (1961). Satellite cell of skeletal muscle fibers. Journal of Biophysical and Biochemical Cytology, 9 (2), 493–495. https://doi.org/10.1083/jcb.9.2.493
Pawlikowski, B., Pulliam, C., Betta, N. D., & Olwin, B. B. (2015). Pervasive satellite cell contribution to uninjured adult muscle fibers. Skeletal Muscle, 5 (1), 42. https://doi.org/10.1186/s13395-015-0067-1
Relaix, F., & Zammit, P. S. (2012). Satellite cells are essential for skeletal muscle regeneration: The cell on the edge returns centre stage. Development, 139 (16), 2845–2856. https://doi.org/10.1242/dev.069088
Rodgers, J. T., King, K. Y., & Brunet, A. (2014). mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert. Nature, 510 (7505), 393–396. https://doi.org/10.1038/nature13255
Sousa-Victor, P., Gutarra, S., & Muñoz-Cánoves, P. (2014). Geroconversion of aged muscle stem cells under regenerative pressure. Cell Cycle, 13 (20), 3183–3190. https://doi.org/10.4161/15384101.2014.965072
Yin, H., Price, F., & Rudnicki, M. A. (2013). Satellite cells and the muscle stem cell niche. Physiological Reviews, 93 (1), 23–67. https://doi.org/10.1152/physrev.00043.2011
Downloads
-
Download PDF
Abstract Views: 30, 
Download PDF: 8
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Inventum Biologicum: An International Journal of Biological Research
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
