Myosatellite Cells: The Architects of Muscle Regeneration and Repair

Authors

  • Dr. Mayalata Dimpal Department of Zoology, N. B. Mehta Science College, Bordi, Palghar-401701, India

Keywords:

Myosatellite cells, Skeletal muscle, Regeneration, Stem cells, Muscle repair, Regenerative medicine

Abstract

Myosatellite cells, also referred to as satellite cells, are muscle-specific stem cells that play a crucial role in skeletal muscle regeneration, growth, and repair. These cells sit nestled between the basal lamina and sarcolemma of muscle fibers, and upon activation, they proliferate and differentiate into new myofibers. This monograph gives an overview of the biology, function, and therapeutic potential of myosatellite cells, with integration of recent scientific advances. Their effects in muscle homeostasis, the molecular mechanisms regulating their activation, and the regenerative medicine potential are discussed. Future directions for research and clinical applications conclude the review.

Downloads

Download data is not yet available.

References

Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2013). Building muscle: Molecular regulation of myogenesis. Cold Spring Harbor Perspectives in Biology, 5 (2), a 008342. https://doi.org/10.1101/cshperspect.a008342

Bjornson, C. R., Cheung, T. H., Liu, L., Tripathi, P. V., & Steeper, K. M. (2012). Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells, 30 (2), 232–242. https://doi.org/10.1002/stem.773

Blau, H. M., Cosgrove, B. D., & Ho, A. T. (2015). The central role of muscle stem cells in regenerative failure with aging. Nature Medicine, 21 (8), 854–862. https://doi.org/10.1038/nm.3918

Brack, A. S., Conboy, I. M., & Roy, S. (2008). Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science, 317 (5839), 807–810. https://doi.org/10.1126/science.1144090

Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008). Niche regulation of muscle satellite cell self-renewal and differentiation. Cell Stem Cell, 2 (1), 22–31. https://doi.org/10.1016/j.stem.2007.12.012

Mauro, A. (1961). Satellite cell of skeletal muscle fibers. Journal of Biophysical and Biochemical Cytology, 9 (2), 493–495. https://doi.org/10.1083/jcb.9.2.493

Pawlikowski, B., Pulliam, C., Betta, N. D., & Olwin, B. B. (2015). Pervasive satellite cell contribution to uninjured adult muscle fibers. Skeletal Muscle, 5 (1), 42. https://doi.org/10.1186/s13395-015-0067-1

Relaix, F., & Zammit, P. S. (2012). Satellite cells are essential for skeletal muscle regeneration: The cell on the edge returns centre stage. Development, 139 (16), 2845–2856. https://doi.org/10.1242/dev.069088

Rodgers, J. T., King, K. Y., & Brunet, A. (2014). mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert. Nature, 510 (7505), 393–396. https://doi.org/10.1038/nature13255

Sousa-Victor, P., Gutarra, S., & Muñoz-Cánoves, P. (2014). Geroconversion of aged muscle stem cells under regenerative pressure. Cell Cycle, 13 (20), 3183–3190. https://doi.org/10.4161/15384101.2014.965072

Yin, H., Price, F., & Rudnicki, M. A. (2013). Satellite cells and the muscle stem cell niche. Physiological Reviews, 93 (1), 23–67. https://doi.org/10.1152/physrev.00043.2011

Inventum Biologicum Coverpage

Downloads

Published

13-03-2025

How to Cite

Dimpal, M. (2025). Myosatellite Cells: The Architects of Muscle Regeneration and Repair. Inventum Biologicum: An International Journal of Biological Research, 5(1), 43–45. Retrieved from https://journals.worldbiologica.com/ib/article/view/170

Issue

Vol. 5 No. 1 (2025)

Section

Review article

License

Copyright (c) 2025 Inventum Biologicum: An International Journal of Biological Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.