Helicobacter pylori Induced Neurological Disease and Therapy

Authors

  • Anjana Suresh Department of Microbiology, Centre for Marine Science and Technology (CMST), Rajakkamangalam, Manonmanium Sundarnar University, Tirunelveli, Tamilnadu, India

Keywords:

Gut pathogen, Helicobacter pylori, Inflammatory mediators, Neurological disease

Abstract

About 50% of people worldwide are infected with the gut pathogen Helicobacter pylori. The chance of developing gastric cancer and duodenal and stomach ulcer disease is greatly increased by H. pylori infection, which also causes chronic inflammation. An H. pylori infection typically induces alterations to the gut bacteria and a prolonged inflammatory response, other than from the immediate release of several inflammatory substances, such as chemokines, growth-regulated oncogene, and cytokines. which can be ingested and have an effect throughout the body. If detectable levels of inflammatory mediators remain at both the systemic and local levels, the gut-brain axis or blood-brain barrier will probably to become altered. These proinflammatory factors can cause ischemic stroke, multiple sclerosis, Devic syndrome, Guillain-Barre syndrome, Bickerstaff brainstem encephalitis, Alzheimer's disease, and migraines. They can also cause brain inflammation and the loss of neurons.  Included in this overview are the neurological diseases caused by H. pylori, their eradication, and customized treatments.

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References

Ahn, E. H., Liu, X., Alam, A. M., Kang, S. S., & Ye, K. (2023). Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson’s disease. Molecular Psychiatry, 28(3), 1337–1350. doi:10.1038/s41380-022-01910-2

Altschuler, E. (1996). Gastric Helicobacter pylori infection as a cause of idiopathic Parkinson disease and non-arteric anterior optic ischemic neuropathy. Medical Hypotheses, 47(5), 413–414. doi:10.1016/s0306-9877(96)90223-6

Al Quraan, A. M., Beriwal, N., Sangay, P., & Namgyal, T. (2019). The psychotic impact of Helicobacter pylori gastritis and functional dyspepsia on depression: A systematic review. Cureus, 11(10), e5956. doi:10.7759/cureus.5956

Amieva, M. R., & El-Omar, E. M. (2008). Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology, 134(1), 306–323. doi:10.1053/j.gastro.2007.11.009

Ansari, B., Basiri, K., Meamar, R., Chitsaz, A., & Nematollahi, S. (2015). Association of Helicobacter pylori antibodies and severity of migraine attack. Iranian Journal of Neurology, 14(3), 125–129.

Baj, J., Forma, A., Sitarz, M., Portincasa, P., Garruti, G., Krasowska, D., & Maciejewski, R. (2020). Helicobacter pylori virulence factors-mechanisms of bacterial pathogenicity in the gastric microenvironment. Cells, 10(1), 27. doi:10.3390/cells10010027

Bagaria, A. K., Vyas, A., Mathur, V., Ranawat, C. S., & Singh, M. (2021). Bickerstaff brainstem encephalitis with isolated acute bilateral ophthalmoplegia: An unusual presentation. Annals of Indian Academy of Neurology, 24(4), 624–626. doi:10.4103/aian.AIAN_823_20

Beydoun, M. A., Beydoun, H. A., Shroff, M. R., Kitner-Triolo, M. H., & Zonderman, A. B. (2013). Helicobacter pylori seropositivity and cognitive performance among US adults: Evidence from a large national survey. Psychosomatic Medicine, 75(5), 486–496. doi:10.1097/PSY.0b013e31829108c3

Blum-Degen, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995). Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients. Neuroscience Letters, 202(1–2), 17–20. doi:10.1016/0304-3940(95)12192-7

Brenner, H., Arndt, V., Bode, G., Stegmaier, C., Ziegler, H., & Stümer, T. (2002). Risk of gastric cancer among smokers infected with Helicobacter pylori. International Journal of Cancer, 98(3), 446–449. doi:10.1002/ijc.10201

Budzyński, J., & Kłopocka, M. (2014). Brain-gut axis in the pathogenesis of Helicobacter pylori infection. World Journal of Gastroenterology, 20(18), 5212–5225. doi:10.3748/wjg.v20.i18.5212

Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015). Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health and Disease, 26, 26191. doi:10.3402/mehd.v26.26191

Chiba, A., Kusunoki, S., Shimizu, T., & Kanazawa, I. (1992). Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome. Annals of Neurology, 31(6), 677–679. doi:10.1002/ana.410310619

Chiba, S., Sugiyama, T., Yonekura, K., Tanaka, S., Matsumoto, H., Fujii, N., . . . Sekiguchi, K. (2002). An antibody to VacA of Helicobacter pylori in cerebrospinal fluid from patients with Guillain-Barre syndrome. Journal of Neurology, Neurosurgery, and Psychiatry, 73(1), 76–78. doi:10.1136/jnnp.73.1.76

Chiba, S., Sugiyama, T., Yonekura, K., Tanaka, S., Matsumoto, H., Fujii, N., . . . Hirayama, T. (2004). An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome. Neurology, 63(11), 2184–2186. doi:10.1212/01.wnl.0000145705.82690.04

Cremonini, F., Gabrielli, M., Gasbarrini, G., Pola, P., & Gasbarrini, A. (2004). The relationship between chronic H. pylori infection, CagA seropositivity and stroke: Meta-analysis. Atherosclerosis, 173(2), 253–259. doi:10.1016/j.atherosclerosis.2003.12.012

Cook, K. W., Letley, D. P., Ingram, R. J., Staples, E., Skjoldmose, H., Atherton, J. C., & Robinson, K. (2014). CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa. Gut, 63(10), 1550–1559. doi:10.1136/gutjnl-2013-306253

Dardiotis, E., Sokratous, M., Tsouris, Z., Siokas, V., Mentis, A. A., Aloizou, A. M., . . . Hadjigeorgiou, G. M. (2020). Association between Helicobacter pylori infection and Guillain–Barré syndrome: A meta-analysis. European Journal of Clinical Investigation, 50(5), e13218. doi:10.1111/eci.13218

De Bastiani, R., Gabrielli, M., Ubaldi, E., Benedetto, E., Sanna, G., Cottone, C., . . . Gasbarrini, A. (2008). High prevalence of Cag-A positive H. pylori strains in ischemic stroke: A primary care multicenter study. Helicobacter, 13(4), 274–277. doi:10.1111/j.1523-5378.2008.00610.x

Demir, M., Gokturk, H. S., Ozturk, N. A., Arslan, H., Serin, E., & Yilmaz, U. (2009). Clarithromycin resistance and efficacy of clarithromycin-containing triple eradication therapy for Helicobacter pylori infection in type 2 diabetes mellitus patients. Southern Medical Journal, 102(11), 1116–1120. doi:10.1097/SMJ.0b013e3181bca538

de Sablet, T., Piazuelo, M. B., Shaffer, C. L., Schneider, B. G., Asim, M., Chaturvedi, R., . . . Wilson, K. T. (2011). Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, 60(9), 1189–1195. doi:10.1136/gut.2010.234468

del Zoppo, G. J., & Hallenbeck, J. M. (2000). Advances in the vascular pathophysiology of ischemic stroke. Thrombosis Research, 98(3), 73–81. doi:10.1016/s0049-3848(00)00218-8

Di Battista, A. M., Heinsinger, N. M., & Rebeck, G. W. (2016). Alzheimer’s disease genetic risk factor APOE-ε4 also affects normal brain function. Current Alzheimer Research, 13(11), 1200–1207. doi:10.2174/1567205013666160401115127

Dimachkie, M. M., & Barohn, R. J. (2013). Guillain–Barré syndrome and variants. Neurologic Clinics, 31(2), 491–510. doi:10.1016/j.ncl.2013.01.005

Dickey, W., Kenny, B. D., & McConnell, J. B. (1996). Effect of proton pump inhibitors on the detection of Helicobacter pylori in gastric biopsies. Alimentary Pharmacology and Therapeutics, 10(3), 289–293. doi:10.1111/j.0953-0673.1996.00289.x

Doulberis, M., Kotronis, G., Thomann, R., Polyzos, S. A., Boziki, M., Gialamprinou, D., . . . Kountouras, J. (2018). Review: Impact of Helicobacter pylori on Alzheimer’s disease: What do we know so far? Helicobacter, 23(1), doi:10.1111/hel.12454

Dobbs, R. J., Charlett, A., Purkiss, A. G., Dobbs, S. M., Weller, C., & Peterson, D. W. (1999). Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. Acta Neurologica Scandinavica, 100(1), 34–41. doi:10.1111/j.1600-0404.1999.tb00721.x

Faraji, F., Zarinfar, N., Zanjani, A. T., & Morteza, A. (2012). The effect of Helicobacter pylori eradication on migraine: A randomized, double blind, controlled trial. Pain Physician, 15(6), 495–498.

Feng, L. Y., Yao, X. X., & Jiang, S. L. (2005). Effects of killing Helicobacter pylori quadruple therapy on peptic ulcer: A randomized double-blind clinical trial. World Journal of Gastroenterology, 11(7), 1083–1086. doi:10.3748/wjg.v11.i7.1083

Fuccio, L., Eusebi, L. H., & Bazzoli, F. (2010). Gastric cancer, Helicobacter pylori infection and other risk factors. World Journal of Gastrointestinal Oncology, 2(9), 342–347. doi:10.4251/wjgo.v2.i9.342

Fox, J. G., Dewhirst, F. E., Tully, J. G., Paster, B. J., Yan, L., Taylor, N. S., . . . Ward, J. M. (1994). Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. Journal of Clinical Microbiology, 32(5), 1238–1245. doi:10.1128/jcm.32.5.1238-1245.1994

Gavalas, E., Kountouras, J., Deretzi, G., Boziki, M., Grigoriadis, N., Zavos, C., & Venizelos, I. (2007). Helicobacter pylori and multiple sclerosis. Journal of Neuroimmunology, 188(1–2), 187–9; author reply 190. doi:10.1016/j.jneuroim.2007.06.007

Gravina, A. G., Zagari, R. M., De Musis, C., Romano, L., Loguercio, C., & Romano, M. (2018). Helicobacter pylori and extragastric diseases: A review. World Journal of Gastroenterology, 24(29), 3204–3221. doi:10.3748/wjg.v24.i29.3204

Gravina, A. G., Zagari, R. M., De Musis, C., Romano, L., Loguercio, C., & Romano, M. (2018). Helicobacter pylori and extragastric diseases: A review. World Journal of Gastroenterology, 24(29), 3204–3221. doi:10.3748/wjg.v24.i29.3204

Graham, D. Y., & Qureshi, W. A. (2000). Antibiotic-resistant H. pylori infection and its treatment. Current Pharmaceutical Design, 6(15), 1537–1544. doi:10.2174/1381612003399077

Graham, D. Y. (2015). Helicobacter pylori update: Gastric cancer, reliable therapy, and possible benefits. Gastroenterology, 148(4), 719–31.e3. doi:10.1053/j.gastro.2015.01.040

Graham, D. Y., & Lee, S. Y. (2015). How to effectively use bismuth quadruple therapy: The good, the bad, and the ugly. Gastroenterology Clinics of North America, 44(3), 537–563. doi:10.1016/j.gtc.2015.05.003

Goldenberg, M. M. (2012). Multiple sclerosis review. P and T: A Peer-Reviewed Journal for Formulary Management, 37(3), 175–184.

Gorlé, N., Bauwens, E., Haesebrouck, F., Smet, A., & Vandenbroucke, R. E. (2020). Helicobacter and the Potential Role in Neurological Disorders: There Is More than Helicobacter pylori. Frontiers in Immunology, 11, 584165. doi:10.3389/fimmu.2020.584165

Hafer-Macko, C. E., Sheikh, K. A., Li, C. Y., Ho, T. W., Cornblath, D. R., McKhann, G. M., . . . Griffin, J. W. (1996). Immune attack on the Schwann cell surface in acute inflammatory demyelinating polyneuropathy. Annals of Neurology, 39(5), 625–635. doi:10.1002/ana.410390512

Harris, A. (2001). Treatment of Helicobacter pylori. World Journal of Gastroenterology, 7(3), 303–307. doi:10.3748/wjg.v7.i3.303

Ho, T. W., Mishu, B., Li, C. Y., Gao, C. Y., Cornblath, D. R., Griffin, J. W., . . . McKhann, G. M. (1995). Guillain–Barré syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies. Brain: A Journal of Neurology, 118(3), 597–605. doi:10.1093/brain/118.3.597

Hosseinzadeh, M., Khosravi, A., Saki, K., & Ranjbar, R. (2011). Evaluation of Helicobacter pylori infection in patients with common migraine headache. Archives of Medical Science: AMS, 7(5), 844–849. doi:10.5114/aoms.2011.25560

Jacobs, B. C., Rothbarth, P. H., van der Meché, F. G., Herbrink, P., Schmitz, P. I., de Klerk, M. A., & van Doorn, P. A. (1998). The spectrum of antecedent infections in Guillain–Barré syndrome: A case-control study. Neurology, 51(4), 1110–1115. doi:10.1212/wnl.51.4.1110

Jain, U., Saxena, K., & Chauhan, N. (2021). Helicobacter pylori induced reactive oxygen species: A new and developing platform for detection. Helicobacter, 26(3), e12796. doi:10.1111/hel.12796

Jarius, S., & Wildemann, B. (2010). AQP4 antibodies in neuromyelitis optica: Diagnostic and pathogenetic relevance. Nature Reviews. Neurology, 6(7), 383–392. doi:10.1038/nrneurol.2010.72

Jaruvongvanich, V., Sanguankeo, A., Jaruvongvanich, S., & Upala, S. (2016). Association between Helicobacter pylori infection and multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis and Related Disorders, 7, 92–97. doi:10.1016/j.msard.2016.03.013

Kabeer, K. K., Ananthakrishnan, N., Anand, C., & Balasundaram, S. (2017). Prevalence of Helicobacter pylori infection and stress, anxiety or depression in functional dyspepsia and outcome after appropriate intervention. Journal of Clinical and Diagnostic Research, 11(8), VC11–VC15. doi:10.7860/JCDR/2017/26745.10486

Kira, J. I., & Isobe, N. (2019). Helicobacter pylori infection and demyelinating disease of the central nervous system. Journal of Neuroimmunology, 329, 14–19. doi:10.1016/j.jneuroim.2018.06.017

Kountouras, J., Deretzi, G., Gavalas, E., Zavos, C., Polyzos, S. A., Kazakos, E., . . . Giouleme, O. (2014). A proposed role of human defensins in Helicobacter pylori-related neurodegenerative disorders. Medical Hypotheses, 82(3), 368–373. doi:10.1016/j.mehy.2013.12.025

Kountouras, J., Boziki, M., Polyzos, S. A., Katsinelos, P., Gavalas, E., Zeglinas, C., . . . Deretzi, G. (2017). Impact of reactive oxygen species generation on Helicobacter pylori-related extragastric diseases: A hypothesis. Free Radical Research, 51(1), 73–79. doi:10.1080/10715762.2016.1271122

Kountouras, J., Tsolaki, M., Gavalas, E., Boziki, M., Zavos, C., Karatzoglou, P., . . . Venizelos, I. (2006). Relationship between Helicobacter pylori infection and Alzheimer disease. Neurology, 66(6), 938–940. doi:10.1212/01.wnl.0000203644.68059.5f

Kountouras, J., Mylopoulos, N., Chatzopoulos, D., Zavos, C., Boura, P., Konstas, A. G., & Venizelos, J. (2002). Eradication of Helicobacter pylori may be beneficial in the management of chronic open-angle glaucoma. Archives of Internal Medicine, 162(11), 1237–1244. doi:10.1001/archinte.162.11.1237

Kountouras, J., Tsolaki, F., Tsolaki, M., Gavalas, E., Zavos, C., Polyzos, S. A., . . . Deretzi, G. (2016). Helicobacter pylori-related ApoE 4 polymorphism may be associated with dysphagic symptoms in older adults. Diseases of the Esophagus, 29(7), 842. doi:10.1111/dote.12364

Kountouras, J., Deretzi, G., Zavos, C., Karatzoglou, P., Touloumis, L., Nicolaides, T., . . . Venizelos, I. (2005). Association between Helicobacter pylori infection and acute inflammatory demyelinating polyradiculoneuropathy. European Journal of Neurology, 12(2), 139–143. doi:10.1111/j.1468-1331.2004.00977.x

Kusunoki, S. (2023). Antibodies to glycolipids in Guillain–Barré syndrome, Miller Fisher syndrome and related autoimmune neurological diseases. Advances in Neurobiology, 29, 479–495. doi:10.1007/978-3-031-12390-0_16

Liu, L., Huh, J. R., & Shah, K. (2022). Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS. EBiomedicine, 77, 103908. doi:10.1016/j.ebiom.2022.103908

Lina, T. T., Alzahrani, S., Gonzalez, J., Pinchuk, I. V., Beswick, E. J., & Reyes, V. E. (2014). Immune evasion strategies used by Helicobacter pylori. World Journal of Gastroenterology, 20(36), 12753–12766. doi:10.3748/wjg.v20.i36.12753

Liston, A., Kohler, R. E., Townley, S., Haylock-Jacobs, S., Comerford, I., Caon, A. C., . . . McColl, S. R. (2009). Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response. Journal of Immunology. Baltimore, MD, 182(5), 3121–3130. doi:10.4049/jimmunol.0713169

Li, W., Minohara, M., Piao, H., Matsushita, T., Masaki, K., Matsuoka, T., . . . Kira, J. (2009). Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. Multiple Sclerosis, 15(12), 1411–1421. doi:10.1177/1352458509348961

Liou, J. M., Malfertheiner, P., Lee, Y. C., Sheu, B. S., Sugano, K., Cheng, H. C., . . . Asian Pacific Alliance on Helicobacter and Microbiota (APAHAM). (2020). Screening and eradication of Helicobacter pylori for gastric cancer prevention: The Taipei global consensus. Gut, 69(12), 2093–2112. doi:10.1136/gutjnl-2020-322368

Lin, T. F., & Hsu, P. I. (2018). Second-line rescue treatment of Helicobacter pylori infection: Where are we now? World Journal of Gastroenterology, 24(40), 4548–4553. doi:10.3748/wjg.v24.i40.4548

Malaguarnera, M., Bella, R., Alagona, G., Ferri, R., Carnemolla, A., & Pennisi, G. (2004). Helicobacter pylori and Alzheimer’s disease: A possible link. European Journal of Internal Medicine, 15(6), 381–386. doi:10.1016/j.ejim.2004.05.008

Mégraud, F., & Lehours, P. (2007). Helicobacter pylori detection and antimicrobial susceptibility testing. Clinical Microbiology Reviews, 20(2), 280–322. doi:10.1128/CMR.00033-06

Mridula, K. R., Borgohain, R., Chandrasekhar Reddy, V., Bandaru, V. C. h., & Suryaprabha, T. (2017). Association of Helicobacter pylori with Parkinson’s disease. Journal of Clinical Neurology, 13(2), 181–186. doi:10.3988/jcn.2017.13.2.181

Montecucco, C., & de Bernard, M. (2003). Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori. Microbes and Infection, 5(8), 715–721. doi:10.1016/s1286-4579(03)00124-2

Moran, A. P., & Prendergast, M. M. (2001). Molecular mimicry in Campylobacter jejuni and Helicobacter pylori lipopolysaccharides: Contribution of gastrointestinal infections to autoimmunity. Journal of Autoimmunity, 16(3), 241–256. doi:10.1006/jaut.2000.0490

Nagayama, H., Kajimoto, Y., Kumagai, T., Nishiyama, Y., Mishina, M., & Kimura, K. (2015). Pharmacokinetics of levodopa before and after gastrointestinal resection in Parkinson’s disease. Case Reports in Neurology, 7(3), 181–185. doi:10.1159/000381181

Park, A. M., & Tsunoda, I. (2022). Helicobacter pylori infection in the stomach induces neuroinflammation: The potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer’s disease. Inflammation and Regeneration, 42(1), 39. doi:10.1186/s41232-022-00224-8

Perry, V. H., Nicoll, J. A., & Holmes, C. (2010). Microglia in neurodegenerative disease. Nature Reviews. Neurology, 6(4), 193–201. doi:10.1038/nrneurol.2010.17

Polenghi, A., Bossi, F., Fischetti, F., Durigutto, P., Cabrelle, A., Tamassia, N., . . . de Bernard, M. (2007). The neutrophil-activating protein of Helicobacter pylori crosses endothelia to promote neutrophil adhesion in vivo. Journal of Immunology. Baltimore, MD, 178(3), 1312–1320. doi:10.4049/jimmunol.178.3.1312

Rahne, K. E., Tagesson, C., & Nyholm, D. (2013). Motor fluctuations and Helicobacter pylori in Parkinson’s disease. Journal of Neurology, 260(12), 2974–2980. doi:10.1007/s00415-013-7089-6

Ranjbar, R., Karampoor, S., & Jalilian, F. A. (2019). The protective effect of Helicobacter pylori infection on the susceptibility of multiple sclerosis. Journal of Neuroimmunology, 337, 577069. doi:10.1016/j.jneuroim.2019.577069

Ribaldone, D. G., Fagoonee, S., Hickman, I., Altruda, F., Saracco, G. M., & Pellicano, R. (2016). Helicobacter pylori infection and ischemic heart disease: Could experimental data lead to clinical studies? Minerva Cardioangiologica, 64(6), 686–696.

Rodrigues-Amorim, D., Rivera-Baltanás, T., Regueiro, B., Spuch, C., de Las Heras, M. E., Vázquez-Noguerol Méndez, R., . . . Agís-Balboa, R. C. (2018). The role of the gut microbiota in schizophrenia: Current and future perspectives. World Journal of Biological Psychiatry: The Official Journal of the World Federation of Societies of Biological Psychiatry, 19(8), 571–585. doi:10.1080/15622975.2018.1433878

Roubaud Baudron, C., Letenneur, L., Langlais, A., Buissonnière, A., Mégraud, F., Dartigues, J. F., . . . Personnes Agées QUID Study. (2013). Does Helicobacter pylori infection increase incidence of dementia? The Personnes Agées QUID Study. Journal of the American Geriatrics Society, 61(1), 74–78. doi:10.1111/jgs.12065

Robinson, K., Argent, R. H., & Atherton, J. C. (2007). The inflammatory and immune response to Helicobacter pylori infection. Best Practice and Research. Clinical Gastroenterology, 21(2), 237–259. doi:10.1016/j.bpg.2007.01.001

Sanders, M. K., & Peura, D. A. (2002). Helicobacter pylori-associated diseases. Current Gastroenterology Reports, 4(6), 448–454. doi:10.1007/s11894-002-0019-x

Safavi, M., Sabourian, R., & Foroumadi, A. (2016). Treatment of Helicobacter pylori infection: Current and future insights. World Journal of Clinical Cases, 4(1), 5–19. doi:10.12998/wjcc.v4.i1.5

Sellner, J., Hemmer, B., & Mühlau, M. (2010). The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes. Journal of Autoimmunity, 34(4), 371–379. doi:10.1016/j.jaut.2009.09.013

Sticlaru, L., Stăniceanu, F., Cioplea, M., Nichita, L., Bastian, A., Micu, G., & Popp, C. (2019). Dangerous liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study. Analytical Cellular Pathology, 2019, 3085181. doi:10.1155/2019/3085181

Shen, X., Yang, H., Wu, Y., Zhang, D., & Jiang, H. (2017). Meta-analysis: Association of Helicobacter pylori infection with Parkinson’s diseases. Helicobacter, 22(5), doi:10.1111/hel.12398

Soboka, M., Gudina, E. K., Gashaw, M., Amare, H., Berhane, M., Desalegn, H., . . . Tesfaye, M. (2022). Depression among people with dyspepsia and H. pylori infection: A community based cross-sectional study in Ethiopia. PLOS ONE, 17(10), e0275424. doi:10.1371/journal.pone.0275424

Sriwastava, S., Kataria, S., Tandon, M., Patel, J., Patel, R., Jowkar, A., . . . Lisak, R. P. (2021). Guillain Barré Syndrome and its variants as a manifestation of COVID-19: A systematic review of case reports and case series. Journal of the Neurological Sciences, 420, 117263. doi:10.1016/j.jns.2020.117263

Su, J., Zhou, X. Y., & Zhang, G. X. (2014). Association between Helicobacter pylori infection and migraine: A meta-analysis. World Journal of Gastroenterology, 20(40), 14965–14972. doi:10.3748/wjg.v20.i40.14965

Sutton, P., & Boag, J. M. (2019). Status of vaccine research and development for Helicobacter pylori. Vaccine, 37(50), 7295–7299. doi:10.1016/j.vaccine.2018.01.001

Tunca, A., Türkay, C., Tekin, O., Kargili, A., & Erbayrak, M. (2004). Is Helicobacter pylori infection a risk factor for migraine? A case-control study. Acta Neurologica Belgica, 104(4), 161–164.

Talebi Bezmin Abadi, A. A. (2016). Vaccine against Helicobacter pylori: Inevitable approach. World Journal of Gastroenterology, 22(11), 3150–3157. doi:10.3748/wjg.v22.i11.3150

Uberti, A. F., Callai-Silva, N., Grahl, M. V. C., Piovesan, A. R., Nachtigall, E. G., Furini, C. R. G., & Carlini, C. R. (2022). Helicobacter pylori urease: Potential contributions to Alzheimer’s disease. International Journal of Molecular Sciences, 23(6), 3091. doi:10.3390/ijms23063091

Villarán, R. F., Espinosa-Oliva, A. M., Sarmiento, M., De Pablos, R. M., Argüelles, S., Delgado-Cortés, M. J., . . . Machado, A. (2010). Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: Potential risk factor in Parkinson’s disease. Journal of Neurochemistry, 114(6), 1687–1700. doi:10.1111/j.1471-4159.2010.06879.x

White, J. R., Winter, J. A., & Robinson, K. (2015). Differential inflammatory response to Helicobacter pylori infection: Etiology and clinical outcomes. Journal of Inflammation Research, 8, 137–147. doi:10.2147/JIR.S64888

Wroblewski, L. E., Peek, R. M., Jr., & Wilson, K. T. (2010). Helicobacter pylori and gastric cancer: Factors that modulate disease risk. Clinical Microbiology Reviews, 23(4), 713–739. doi:10.1128/CMR.00011-10

Wijdicks, E. F., & Klein, C. J. (2017). Guillain–Barré syndrome. Mayo Clinic Proceedings, 92(3), 467–479. doi:10.1016/j.mayocp.2016.12.002

Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007). The spectrum of neuromyelitis optica. Lancet. Neurology, 6(9), 805–815. doi:10.1016/S1474-4422(07)70216-8

Yao, G., Wang, P., Luo, X. D., Yu, T. M., Harris, R. A., & Zhang, X. M. (2016). Meta-analysis of association between Helicobacter pylori infection and multiple sclerosis. Neuroscience Letters, 620, 1–7. doi:10.1016/j.neulet.2016.03.037

Yamamoto, M., Inokuchi, R., Nakamura, K., & Yahagi, N. (2012). Bickerstaff’s brainstem encephalitis associated with ulcerative colitis. BMJ Case Reports, 2012. doi:10.1136/bcr-2012-007013

Yuki, N., Sato, S., Tsuji, S., Hozumi, I., & Miyatake, T. (1993). An immunologic abnormality common to Bickerstaff’s brain stem encephalitis and Fisher’s syndrome. Journal of the Neurological Sciences, 118(1), 83–87. doi:10.1016/0022-510x(93)90250-3

Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., . . . Chen, X. (2020). The progress of gut microbiome research related to brain disorders. Journal of Neuroinflammation, 17(1), 25. doi:10.1186/s12974-020-1705-z

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21-03-2023

How to Cite

Suresh, A. (2023). Helicobacter pylori Induced Neurological Disease and Therapy. Inventum Biologicum: An International Journal of Biological Research, 3(1), 5–17. Retrieved from https://journals.worldbiologica.com/ib/article/view/30

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Review article