An In-Depth Review of Liquisolid Compact Techniques: Principles, Applications and Characterizations

Abstract

For the majority of therapeutic agents, oral drug administration has proven to be one of the most practical and widely recognised methods of delivery. Because of its clear benefits of convenience, better patient compliance, and ease of administration, it is one of the most often utilised drug delivery methods. A unique idea in medication delivery, the Liquisolid Compact System can alter the pace at which pharmaceuticals that are insoluble in water dissolve. A more modern method known as "powdered solution technology," also known as "Liquisolid technology," has been used to turn medications that are insoluble in water into fast-acting solid dosage forms. One of the industry's most difficult challenges in creating the perfect solid dosage form unit is the restricted solubility of pharmaceuticals. The liquidsolid strategy is a fresh and effective way to deal with this outcome. The method is predicated on dissolving the insoluble drug in a non-volatile solvent and combining drug-loaded solutions with suitable carriers and coating materials to create powders that flow and compress into acceptable forms. The specific chemical moieties have no bearing on the choice of non-toxic hydrophilic solvent, carrier, coating materials, or their ratios. Either a larger surface area of the drug that is accessible for release, an increase in the drug's aqueous solubility, or better wettability of the drug particles are the causes of the higher bioavailability.