Herbal Interventions for Urolithiasis: A Systematic Evaluation of Efficacy and Safety

Authors

  • M.R. Eromedogane Department of Health and Wellbeing, Faculty of Biomedicine, Delta State University, Asaba Campus, Nigeria
  • J.H. Okantu Department of Health and Wellbeing, Faculty of Biomedicine, Delta State University, Asaba Campus, Nigeria
  • E.L. Ebawun Department of Health and Wellbeing, Faculty of Biomedicine, Delta State University, Asaba Campus, Nigeria

Keywords:

Urolithiasis, Molecular mechanism, Traditional plants, Lead compound

Abstract

Urolithiasis, the process of stone formation in the kidney, bladder, and/or urethra (urinary tract), is a condition affecting 12% of the global population, as per the World Health Organization (WHO). The prevalence is higher in males, ranging from 70-81%, compared to females, where it ranges from 47-60%, resulting in a gender ratio of 2.4:1. Traditional plants contain diverse chemical constituents that exert positive effects on lithiasis through various molecular mechanisms. Several medicinal plants, including Moringa oleifera, Crataeva magna, Aerva javanica, Peperomia tetraphylla, Terminalia bellirica, Ipomoea eriocarpa, Punica granatum, Hibiscus rosasinensis, Costus spiralis, and Herniaria hirsuta, exhibit antiurolithiatic effects. This review aims to present information and highlight current trends in research on medicinal plants with antiurolithiatic activity. The insights provided in this review may aid in the identification of lead compounds or herbal products responsible for antiurolithiatic activity.

Downloads

Download data is not yet available.

References

Aggarwal, K. P., Narula, S., Kakkar, M., & Tandon, C. (2013). Nephrolithiasis: Molecular mechanism of renal stone formation and the critical role played by modulators. BioMed Research International, 2013, 292953. https://doi.org/10.1155/2013/292953

Alelign, T., & Petros, B. (2018). Kidney stone disease: An update on current concepts. Advances in Urology, 2018, 3068365. https://doi.org/10.1155/2018/3068365

Basavaraj, D. R., Biyani, C. S., Browning, A. J., & Cartledge, J. J. (2007). The role of urinary kidney stone inhibitors and promoters in the pathogenesis of calcium containing renal stones. EAU-EBU Update Series, 5(3), 126–136. https://doi.org/10.1016/j.eeus.2007.03.002

Coe, F. L., Evan, A., & Worcester, E. (2005). Kidney stone disease. Journal of Clinical Investigation, 115(10), 2598–2608. https://doi.org/10.1172/JCI26662

Dawson, C. H., & Tomson, C. R. (2012). Kidney stone disease: Pathophysiology, investigation and medical treatment. Clinical Medicine, 12(5), 467–471. https://doi.org/10.7861/clinmedicine.12-5-467

Esmail Al-Snafi, A. (2015). Medicinal plants with anti urolithiatic effects. International Journal of Pharmacy, 5(2), 98–103.

Jayaraman, U. C., & Gurusamy, A. (2018). Review on Uro-lithiasis pathophysiology and Aesculapian discussion. IOSR Journal of Pharmacy, 8(2), 30–42.

Pareta, S. K., Patra, K. C., Mazumder, P. M., & Sasmal, D. (2011). Establishing the principle of herbal therapy for antiurolithiatic activity: A review. Journal of Pharmacology and Toxicology, 6(3), 321–332. https://doi.org/10.3923/jpt.2011.321.332

Ratkalkar, V. N., & Kleinman, J. G. (2011). Mechanisms of stone formation. Clinical Reviews in Bone and Mineral Metabolism, 9(3–4), 187–197. https://doi.org/10.1007/s12018-011-9104-8

Russinko, P. J., Agarwal, S., Choi, M. J., & Kelty, P. J. (2003). Obstructive nephropathy secondary to sulfasalazine calculi. Urology, 62(4), 748. https://doi.org/10.1016/s0090-4295(03)00666-6

Russinko, P. J., Agarwal, S., Choi, M. J., & Kelty, P. J. (2003). Obstructive nephropathy secondary to sulfasalazine calculi. Urology, 62(4), 748. https://doi.org/10.1016/s0090-4295(03)00666-6

Stoller, M. L. (2009). MD maxwell V. Meng MD, Urinary stone disease the practical guide to medical and surgical management. Annals of the Royal College of Surgeons of England, 91(5), 448.

Thenmozhi, P., Saravana Guru, S. P., Kannan, M., & Sathiyarajeswaran, P. (2016). Overview on selected medicinal plants used in the management of urolithiasis. World Journal of Pharmacy and Pharmaceutical Sciences, 5(10), 280–294.

Thomas, A., Woodard, C., Rovner, E. S., & Wein, A. J. (2003). Urologic complications of nonurologic medications. Urologic Clinics of North America, 30(1), 123–131. https://doi.org/10.1016/s0094-0143(02)00111-8

Wang, S., Huang, X., Xu, Q., & Xu, T. (2017). Research progress of mechanisms of ceftriaxone associated nephrolithiasis. Mini Reviews in Medicinal Chemistry, 17(17), 1584–1587. https://doi.org/10.2174/1389557516666160801092713

Whelan, C., & Schwartz, B. F. (2004). Bilateral guaifenesin ureteral calculi. Urology, 63(1), 175–176. https://doi.org/10.1016/j.urology.2003.09.047

Ziemba, J. B., & Matlaga, B. R. (2017). Epidemiology and economics of nephrolithiasis. Investigative and Clinical Urology, 58(5), 299–306. https://doi.org/10.4111/icu.2017.58.5.299

Downloads

Published

22-09-2023

How to Cite

Eromedogane, M., Okantu, J., & Ebawun, E. (2023). Herbal Interventions for Urolithiasis: A Systematic Evaluation of Efficacy and Safety. Inventum Biologicum: An International Journal of Biological Research, 3(3), 78–82. Retrieved from https://journals.worldbiologica.com/ib/article/view/63

Issue

Vol. 3 No. 3 (2023)

Section

Review article

License

Copyright (c) 2023 Inventum Biologicum: An International Journal of Biological Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.